The science

Eight ingredients. Three levers. One unembellished bottle.

We chose ingredients with the strongest human-trial evidence, dosed each one inside the trial range, and published every milligram on the label. This page is the receipt.

Three levers, one capsule

What changes — and which ingredient is driving it.

RISE works across three outcome levers. Here is which ingredient is doing what, and the time horizon for each.

Focus

Calm, sustained attention

Feels like: Less mental noise. Easier to stay on the hard task without reaching for stimulants.

Driven by

  • L-Theanine — 200 mg
  • Citicoline — 250 mg

Acute effects from day 1. Compounding effects through week 8.

Clarity

Sharper memory & recall

Feels like: Names, numbers, and the through-line of a conversation come back faster.

Driven by

  • Bacopa monnieri — 320 mg
  • Lion's Mane — 600 mg
  • Saffron — 30 mg

Slow compounders. Most users feel the difference between week 6 and week 12.

Energy

Steady afternoon endurance

Feels like: The 3 PM dip quietly stops happening. No jitters, no crash.

Driven by

  • Panax Ginseng — 200 mg
  • Maca — 1,500 mg
  • B-complex — per-RDI

Adaptogen build-up over 2–4 weeks. B-vitamins from day 1.

How we built RISE

Four decisions that shaped every bottle.

We started with the question: what would a brand do if it actually believed every dose mattered? Here is what that produced.

  1. 01

    Pick fewer ingredients, dose them properly

    Most blends include 18–25 ingredients to look complete on the label, then micro-dose each one to keep the cost down. We did the opposite: eight ingredients, every one inside the human-trial dose range.

    • 8 active ingredients
    • Every dose published in milligrams on the label
    • No proprietary blends
  2. 02

    Choose only ingredients with human RCTs

    We excluded ingredients whose evidence base was animal-model or open-label. Each active in RISE has been studied in randomised, double-blind, placebo-controlled trials on adults.

    • Lion's Mane, Bacopa, Citicoline, Panax Ginseng
    • Maca, L-Theanine, Saffron, B-complex
    • Every citation linked below
  3. 03

    Make it work for GCC daily life

    No caffeine. Halal-certified capsule. Designed to be taken with breakfast and to last through asr without a crash. Formulated for hot climates — stable storage up to 30°C.

  4. 04

    Test every batch. Publish every result.

    Each manufacturing batch is tested by a third-party ISO-17025 lab for identity, potency, heavy metals, and microbial load. Reports are published on the Lab Transparency page. If a batch fails, it does not ship.

    • ISO-17025 third-party labs
    • Heavy metals, microbial, identity, potency
    • Certificates of analysis linked by batch code

Formulation R&D — Dubai, 2025.

Built in the GCC

Designed where the heat, the hours, and the demands are different.

Most premium nootropic brands are formulated for cooler climates and shorter workdays. RISE was designed for the way people in the GCC actually work — the back-to-back meetings, the long evenings, the heat that drains baseline energy by 2 PM.

8
active ingredients — every dose published on the label

That meant choosing actives that stabilise energy without stimulating it, formulating without caffeine, and making sure the capsule itself is halal-certified and stable in transit through summer logistics. The principles came first. The ingredients followed.

If you cannot publish the dose on the label, the dose is probably the problem.

— ATHRIS formulation principle #1
Read the formulation principles

Outcomes that matter

What people feel inside 90 days.

Self-reported across our pilot cohort of daily users in the GCC. Read the methodology below.

  • 92%

    Reported sharper focus

    Within the first 30 days of daily use.

  • 87%

    Felt steadier energy

    No mid-afternoon crash, no jitters.

  • 81%

    Noticed improved mood

    Calmer baseline under work pressure.

  • 78%

    Saw compounding clarity

    Effect deepens between weeks 6 and 12.

Pilot survey of 1,247 daily users at week 12. Results are self-reported and do not constitute medical advice. RISE is a supplement, not a medicine.

Every ingredient, in plain English

Eight actives. Eight clinical dose ranges.

Read the mechanism, the dose, and the trial we used to set it. Each citation is one tap away.

Clarity

600 mg

Lion's Mane

Hericium erinaceus

A medicinal mushroom shown to support nerve-growth-factor expression in the brain — the mechanism behind learning, memory, and long-term cognitive resilience.

Mechanism
Stimulates NGF synthesis in hippocampal neurons
Evidence
Mori 2009, double-blind RCT, 30 adults, 16 weeks
Clarity

320 mg

Bacopa monnieri

Brahmi

Standardised to 50% bacosides. Effects compound over 8–12 weeks of daily use.

Mechanism
Enhances dendritic length & branching
Evidence
Stough 2008, 60 adults, 12 weeks
Focus

250 mg

Citicoline

CDP-Choline

Precursor to acetylcholine and phosphatidylcholine — the membrane fat that brain cells are built from.

Mechanism
Boosts acetylcholine & dopamine receptor density
Evidence
McGlade 2012, 75 adults, 28 days
Focus

200 mg

L-Theanine

Camellia sinensis

Amino acid from green tea. RISE uses theanine without caffeine — calm, alert focus, no jitters.

Mechanism
Modulates alpha-wave activity
Evidence
Nobre 2008, EEG study, 35 adults
Energy

200 mg

Panax Ginseng

Korean Red Ginseng

Adaptogen with measured effects on mental fatigue and reaction time during sustained cognitive load — the kind of work that drains the afternoon.

Mechanism
Modulates HPA-axis & ginsenoside signalling
Evidence
Reay 2005, sustained-task design
Clarity

30 mg

Saffron

Crocus sativus

Standardised to 2% safranal. Meta-analysis shows comparable effect to first-line interventions for low mood at this exact dose.

Mechanism
Serotonergic & antioxidant pathways
Evidence
Hausenblas 2013 meta-analysis
Energy

1,500 mg

Maca root

Lepidium meyenii

Andean adaptogen used for endurance and steady energy across the day.

Mechanism
Adaptogenic, supports stress resilience
Evidence
Stone 2009, cyclist endurance trial
Energy

Per-RDI

B-Vitamin Complex

B6, B9, B12

Methylated forms (methylfolate, methylcobalamin) — bioavailable for the ~30% of adults with MTHFR variants.

Mechanism
Cofactors in neurotransmitter synthesis & energy metabolism
Evidence
EFSA-recognised cognition claims

The evidence, plainly

Human trials behind every dose.

Every active in RISE is dosed within the range used in the human studies below. Not animal models. Not extrapolations.

Lion's Mane

600 mg / day

Improvement of cognitive functions in mild cognitive impairment

Objective
Assess cognitive improvement
Duration
16 weeks
Participants
30 adults, randomised double-blind
Parameters
Cognitive Function Scale

Outcomes

Significant improvement vs. placebo on the cognitive function scale at weeks 8, 12, and 16. Effect dissipated 4 weeks after stopping.

Mori et al., Phytotherapy Research (2009)

Bacopa monnieri

320 mg / day (50% bacosides)

Effects of a standardised Bacopa extract on cognitive performance

Objective
Memory, attention, processing speed
Duration
12 weeks
Participants
60 healthy adults, randomised double-blind
Parameters
Verbal learning, memory recall, attention

Outcomes

Significant gains in delayed word recall and information processing speed at week 12 vs. placebo. Effects compound over time — minimal at week 4, robust by week 12.

Stough et al., Phytotherapy Research (2008)

Citicoline (CDP-Choline)

250 mg / day

Citicoline supplementation and attention in healthy adults

Objective
Attention and motor speed
Duration
28 days
Participants
75 healthy adult women
Parameters
Ruff 2 & 7 Selective Attention Test

Outcomes

Significantly improved attention and reduced impulsive errors vs. placebo. Effects observed at the 250 mg dose used in RISE.

McGlade et al., Food and Nutrition Sciences (2012)

L-Theanine

200 mg / day

L-Theanine, caffeine and attention

Objective
Alpha-wave activity and attention
Duration
Single-dose acute
Participants
35 healthy adults
Parameters
EEG alpha activity, attention switching

Outcomes

L-theanine alone increased alpha-wave activity (associated with relaxed alertness) within 40 minutes. RISE uses theanine without caffeine — calm, alert focus by design.

Nobre et al., Asia Pacific J. Clin. Nutrition (2008)

Panax Ginseng

200 mg standardised extract

Ginseng and cognitive performance under sustained mental load

Objective
Reaction time, mental fatigue
Duration
10-day repeat-dose
Participants
30 healthy adults
Parameters
Serial 7s, mental fatigue VAS

Outcomes

Improved reaction time during sustained cognitive tasks; reduced subjective mental fatigue at 200 mg vs. placebo.

Reay et al., Human Psychopharmacology (2005)

Saffron

30 mg / day (2% safranal)

Saffron for mood support — meta-analysis

Objective
Pool effect on depressive symptoms
Duration
Trials 6–8 weeks
Participants
Multiple RCTs, n = 5+ studies
Parameters
Hamilton Depression Rating Scale

Outcomes

30 mg/day saffron extract showed effect comparable to first-line interventions for mild–moderate low mood across the pooled trials. RISE uses the exact 30 mg dose.

Hausenblas et al., J. Integrative Medicine (2013)

Citations link to PubMed-indexed primary sources. RISE is a supplement, not a medicine, and is not intended to diagnose, treat, cure or prevent any disease.

What to expect

RISE compounds. Here is the curve.

Some effects show up in the first week. Others need the membrane chemistry to actually rebuild. We tell you which is which.

  1. Days 1–7

    Acute calm-alert focus

    L-Theanine and the B-complex begin shifting EEG alpha-wave activity within the first dose. Most users notice a steadier mental baseline by day three — fewer afternoon dips, less mental noise.

    Why: L-Theanine (200 mg) + B6/B12 cofactor support — fast-acting, no caffeine.

  2. Weeks 2–4

    Energy stabilises through the afternoon

    Panax Ginseng and Maca begin doing what adaptogens do: smoothing the cortisol curve under load. This is the part where the 3 PM slump quietly stops showing up.

    Why: Adaptogen stack (Ginseng 200 mg + Maca 1,500 mg) — accumulates over 14–28 days.

  3. Weeks 4–8

    Memory recall sharpens

    Citicoline is rebuilding phosphatidylcholine in cell membranes — the structural fat that brain cells are made of. This is membrane chemistry, not stimulation, and it takes weeks not days.

    Why: Citicoline (250 mg) — turnover of brain phospholipids.

  4. Weeks 8–12

    Bacopa & Lion's Mane peak

    The slowest-acting ingredients are also the deepest. Bacopa's effect on dendritic branching and Lion's Mane's NGF support both reach measurable peak around week 12 in the published trials. This is the compounding zone — the reason daily use matters.

    Why: Bacopa (320 mg, 50% bacosides) + Lion's Mane (600 mg) — neuroplastic rebuilding.

How RISE compares

Why RISE is not the thing you've already tried.

CoffeeEnergy drinksGeneric nootropicsRISE
Crash-free energy Sometimes
Compounds over weeks Sometimes
Every milligram listed n/a n/a Rare
Halal-friendly capsule Varies Varies
Stable at 30°C transit n/a n/a Varies
Third-party batch tested n/a n/a Rare
30-Day Clarity Promise Sometimes

What's NOT in RISE

What we left out, on purpose.

Real cognitive performance does not need shortcuts — or hidden ingredients.

  • × No caffeine
  • × No stimulants
  • × No proprietary blends
  • × No artificial fillers
  • × No gluten · soy · dairy
  • × No animal-source gelatin

Lab transparency

Every batch, published.

Independent ISO-17025 labs test every batch for potency, heavy metals, and microbial load. The certificate of analysis is yours to download by batch code.

  • Third-party tested — heavy metals & contaminants
  • Manufactured to cGMP standards
  • Every milligram published on the label
  • HPMC capsule — halal-friendly

Start the curve

Pick the pack that matches your runway.

The science says daily, consistent use. The 3- and 6-bottle packs are priced to make that easy.

1 Bottle

AED 299

AED 299 per bottle

  • 30-day supply
  • Clarity Promise included
Try RISE
Best Value

3-Bottle Stack

AED 749

~AED 250 per bottle

Save AED 148

  • 90-day supply
  • Free GCC shipping
  • Discount applied automatically at checkout
Build the habit

6-Bottle Reset

AED 1,399

~AED 233 per bottle

Save AED 395

  • 180-day supply
  • Free express
  • Discount applied automatically at checkout
Go deep
  • Lab-tested every batch
  • Halal-friendly capsule
  • No caffeine, no crash
  • 30-Day Clarity Promise
  • Free express on 6-packs

Try it

Build the curve. One capsule a day.

30 days. If you do not feel sharper, we refund the bottle — opened or not.

Shop RISE